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周丛照 教授
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Name: |
Cong-Zhao ZHOU （周丛照） |
| Born: |
November, 1968, Hubei, P. R. China |
| Address: |
School of Life Sciences, University of Science and Technology of China, 230027 Hefei, P. R. China |
| Tel: |
86-551-63600406, 63600407 |
| E-mail: |
zcz@ustc.edu.cn |
| Homepage: |
http://czlab.ustc.edu.cn |
|
EDUCATION
| 1987 – 1992 |
Department of Biology, USTC, Undergraduate Student |
| 1993 – 1995 |
Department of Biology, USTC, Graduate Student |
| 1997 – 2000 |
Department of Biology, University of Science and Technology of China (USTC) and Université Paris-Sud, Ph.D student |
PROFESSIONAL EXPERIENCE
| 1992 – 1993 |
Department of Biology, USTC, Assistant Professor |
| 1997 – 1999 |
Department of Biology, USTC, lecturer |
| 2000 – 2003 |
Laboratoire de Génomique Structurale, CNRS & Université Paris-Sud, Postdoc |
| 2004 – |
School of Life Sciences, USTC, Professor in Biochemistry and Molecular Biology |
RESEARCH INTERESTS
| 1) |
Homeostasis of carbon/nitrogen metabolism in cyanobacteria |
| 2) |
Novel transcription factors: from structure to function |
SELECTED PUBLICATIONS (out of ~100)
| *corresponding author, #contributed equally |
| 1) |
Xie J, Cai K, Hu HX, Jiang YL, Yang F, Hu PF, Cao DD, Li WF, Chen Y*, Zhou CZ*. Structural analysis of the catalytic mechanism and substrate specificity of Anabaena alkaline invertase InvA reveals a novel glucosidase. J Biol Chem. 2016; 291(49):25667-77. |
| 2) |
Yu LY#, Cheng W#, Zhou K#, Li WF, Yu HM, Gao X, Shen X, Wu Q, Chen Y*, Zhou CZ*. Structures of an all-α protein running along the DNA major groove. Nucl Acids Res. 2016; 44(8):3936-45. |
| 3) |
Jia N, Liu N, Cheng W, Jiang YL, Sun H, Chen LL, Peng J, Zhang Y, Ding YH, Zhang ZH, Wang X, Cai G, Wang J, Dong MQ, Zhang Z, Wu H, Wang HW*, Chen Y*, Zhou CZ*. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO Reports. 2016; 17(2): 235-48. |
| 4) |
Hu HX, Jiang YL, Zhao MX, Cai K, Liu SL, Wen B, Lv P, Zhang YH, Peng JH, Zhong H, Yu HM, Ren YM, Zhang ZY, Tian CL, Wu QF, Oliveberg M, Zhang CC*, Chen Y*, Zhou CZ*. Structural insights into HetR-PatS interaction involved in cyanobacterial pattern formation. Sci Rep. 2015 Nov; 5: 16470. |
| 5) |
Bai XH#, Chen HJ#, Jiang YL, Wen Z, Huang Y, Cheng W, Li Q, Qi L, Zhang JR*, Chen Y*, Zhou CZ*. Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. J Biol Chem. 2014; 289(34):23403-16. |
| 6) |
Shi WW#, Jiang YL#, Zhu F, Yang YH, Shao QY, Yang HB, Ren YM, Wu H*, Chen Y*, Zhou CZ*. Structure of a novel O-GlcNAc transferase GtfA reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. J Biol Chem. 2014; 289(30):20898-20907. |
| 7) |
Yang YH#, Jiang YL#, Zhang J, Wang L, Bai XH, Zhang SJ, Ren YM, Li N, Zhang YH, Zhang Z, Gong Q, MEi Y, Xue T, Zhang JR, Chen Y*, Zhou CZ*. Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells. PLoS Pathogens. 2014; 10(6): e1004169. |
| 8) |
Dai YN, Chi CB, Zhou K, Cheng W, Jiang YL, Ren YM, Ruan K, Chen Y, Zhou CZ*. Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase. J Biol Chem. 2013; 288(32):22985-92. |
| 9) |
Hou WT, Li WZ, Chen Y, Jiang YL*, Zhou CZ*. Structures of yeast Apa2 reveal catalytic insights into a canonical Ap4A phosphorylase of the histidine triad superfamily. J Mol Biol. 2013; 425(15):2687-98. |
| 10) |
Yu WL, Jiang YL, Pikis A, Cheng W, Bai XH, Ren YM, Thompson J, Zhou CZ*, Chen Y*. Structural insights into the substrate specificity of a 6-phospho-β-glucosidase BglA-2 from Streptococcus pneumoniae TIGR4. J Biol Chem. 2013; 288(21):14949-58. |
| 11) |
Mu Y#, Lian FM#, Teng YB, Ao J, Jiang YL, He YX, Chen Y, Zhou CZ*, Chen X*. The N-Terminal β-Sheet of peroxiredoxin 4 in the large yellow croaker Pseudosciaena crocea Is Involved in Its Biological Functions. PLoS One. 2013; 8(2):e57061. |
| 12) |
Zhang CC, Zhou CZ. ATPase as a switch in P(II) signal transduction. Proc Natl Acad Sci USA. 2013;110(32):12863-4. |
| 13) |
Guo PC, Ma JD, Jiang YL, Wang SJ, Bao ZZ, Yu XJ, Chen Y, Zhou CZ*. Structure of yeast sulfhydryl oxidase Erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space. J Biol Chem. 2012; 287(42):34961-9 |
| 14) |
Cheng W#, Wang L#, Jiang YL, Bai XH, Chu J, Li Q, Yu G, Liang QL, Zhou CZ* and Chen Y*. Structural insights into the substrate specificity of Streptococcus pneumoniae β(1,3) galactosidase BgaC. J Biol Chem. 2012; 287(27):22910-8. |
| 15) |
Lian FM, Yu J, Ma XX, Yu XJ, Chen Y and Zhou CZ*. Biochemical and structural insights into the catalytic cycle of the yeast peroxiredoxin Ahp1. J Biol Chem. 2012; 287(21):17077-87. |
| 16) |
He YX#, Zhang NN#, Li WF, Jia N, Chen BY, Zhou K, Zhang J, Chen Y and Zhou CZ*. N-terminal domain of Bombyx mori fibroin mediates assembly of the silk in response to the pH decrease. J Mol Biol. 2012; 418(3-4):197-207. |
| 17) |
Jiang YL#, Zhang JW#, Yu WL, Cheng W, Zhang CC, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ* and Chen Y*. Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH. J Biol Chem. 2011; 286(41):35906-14. |
| 18) |
Du Y#, Shi WW#, He YX, Yang YH, Zhou CZ* and Chen Y*. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochem J. 2011; 436: 283-9. |
| 19) |
Ma XX, Guo PC, Shi WW, Luo M, Tan XF, Chen Y and Zhou CZ*. Structural plasticity of the thioredoxin recognition site of yeast methionine-S-sulfoxide reductase Mxr1. J Biol Chem. 2011, 286(15):13430-7. |
| 20) |
Zhang X, Teng YB, Liu JP, He YX, Zhou K, Chen Y and Zhou CZ*. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochem J. 2010; 432(3):445-50. |
| 21) |
Zhao MX#, Jiang YL#, Xu BY, Chen Y, Zhang CC and Zhou CZ*. Crystal structure of cyanobacterial signal transduction protein PII in complex with PipX. J Mol Biol. 2010; 402:552-559. |
| 22) |
Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC* and Zhou CZ*. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci USA. 2010; 107(28) 12487-92. |
| 23) |
Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, and Zhou CZ*. Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. J Mol Biol. 2010; 398(4):614-22. |
| 24) |
He YX#, Huang L#, Xue Y#, Fei X, Teng YB, Rubin-Pitel S, Zhao H* and Zhou CZ*. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2, 4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J Biol Chem. 2010; 285(7):4603-11. |
| 25) |
Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ*. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Reports. 2009; 10(12):1320-6. |
| 26) |
Sun J, Zhang J, Wu F, Xu C, Li S, Zhao W, Wu Z, Wu J, Zhou CZ* and Shi Y*. Solution structure and metal binding properties of Kti11p from Saccharomyces cerevisiae. Biochem. 2005; 44: 8801-9. |
| 27) |
Graille M#, Zhou CZ#, Receveur V, Collinet B, Declerck N and van Tilbeurgh H*. Activation of the LicT transcriptional antiterminator by a domain swing/lock mechanism. J Biol Chem. 2005; 280:14780-9. |
| 28) |
Zhou CZ, de la Sierra-Gallay IL, Quevillon-Cheruel S, Collinet B, Graille M, Blondeau K, Leulliot N, Sorel I, Poupon A, Janin J and van Tilbeurgh H*. Crystal structure of the yeast PX-domain protein Grd19p complexed to phosphatidylinositol-3-phosphate. J Biol Chem. 2003; 278: 50371–6. |
| 29) |
Zhou CZ, Confalonieri F*, Medina N, Esnault C, Zivanovic Y, Yang T, Jacquet M, Janin J, Duguet M, Perasso R and Li ZG. Fine organization of Bombyx mori fibroin heavy chain gene. Nucl Acids Res. 2000; 28(12): 2413-9. |
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