吴 缅 教授
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Name: | Wu Mian (吴缅) |
| Born: | 1953.01 | |
| Address: | School of Life Science, University of Science and Technology of China, 230026 Hefei, P. R. China | |
| Tel: | 86-551-63606264 | |
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| E-mail: | wumian@ustc.edu.cn | |
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主要研究兴趣： 1. p53与肿瘤代谢。 2. 非编码RNA与肿瘤。 主要在研课题： 1.国家自然科学基金委员会重点项目： “p53家族蛋白调控的细胞代谢在肿瘤发生发展中的作用及机制研究”（81430065）,2015.01-2019.12 2. 国家自然科学基金委员会面上项目：“Urdp1和Drf1在细胞分化中作用机制的研究”（31371388）,2014.01-2017.12 代表性论文: 1.Bing Cheng, An Xu, Mengran Qiao, Qiao Wu, Wenyu Wang, Yide Mei and MianWu, BECN1s, a short splice variant of BECN1, functions in mitophagy. Autophagy 2015 Nov 2;11(11):2048-2056. 2.Hao Gu, Qidong Li, Shan Huang, Weiguang Lu, Fangyuan Cheng, Ping Gao，Lin Miao, Yide Mei and Mian Wu. Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signaling. Nature Communications 2015 Jun 2;6:7112 3.Fan Yang, Huafeng Zhang, Yide Mei, and Mian Wu. Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell. 2014 Jan 9;53(1):88-100 4.Wenjing Du, Peng Jiang, Anthony Mancuso, Aaron Stonestrom, Michael D. Brewer, Andy J. Minn, Tak W. Mak, Mian Wu* and Xiaolu Yang*. TAp73 enhances the pentose phosphate pathway and cell proliferation. Nature Cell Biology (2013 Jun 30. doi: 10.1038/ncb2789) 5.Xing Huang, Zhengsheng Wu, Yide Mei and Mian Wu*. X-linked IAP (XIAP) inhibits autophagy via XIAP-Mdm2-p53 signaling. The EMBO Journal ( 2013 Jun 7. doi: 10.1038/emboj) 6.Xingwu Wang, Meng Zha, Xiaocheng Zhao, Peng Jiang, Wenjing Du, Andrew Y. H. Tam, Yide Mei, and Mian Wu*. Siva1 inhibits p53 function by acting as an E3 ubiquitin ligase of ARF. Nature Communications, (2013 March 05DOI 10.1038/ncomms2533) 7.Jin L, Hu WL, Jiang CC, Wang JX, Han CC, Chu P, Zhang LJ, Thorne RF, Wilmott J, Scolyer R, Hersey P, Zhang XD, and Wu M*. MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma. Proc Natl Acad Sci USA. 2011 Sep 20 108 (38 )15840-5 8.Nan Li, Peng Jiang, Wenjing Du, Zhengsheng Wu, Cong Li, Mengran Qiao,Xiaolu Yang, and Mian Wu*. Siva1 inhibits epithelial-mesenchymal transition and metastasis of tumor cells. Proc Natl Acad Sci USA.2011 108 (31) 12851-12856 9.Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M*,Yang X*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology 2011 Mar;13(3):310-6 10.Shanshan Duan, Zhan Yao, Dezhi Hou, Zhengsheng Wu, Wei-guo Zhu and Mian Wu*. Phosphorylation of Pirh2 by Calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO J, 2007 Jul 11;26(13):3062-74. 11.Zhan Yao, Shanshan Duan, Dezhi Hou, Klaus Heese and Mian Wu*. Death effector domain DEDa, a self-cleaved product of Caspase-8/Mch5,translocates to the nucleus by binding to ERK1/2 and up-regulates procaspase-8 expression via a p53-dependent mechanism. The EMBO J, 2007 26，1068-1080 联系方式：members48365365（筹）及中国科技大学生命科学学院，安徽，合肥，230027。电话：0551-63606264；传真：0551-63606264；电子邮件：wumian@ustc.edu.cn |
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